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Faculty Profiles: Trivedi, Vishwa D.

This guide provides information on Bethune-Cookman University faculty, including their research interests, accomplishments and activities, and brief biographical details.

Dr. Vishwa D.Trived

Dr. Vishwa D. Trivedi
Associate Professor, Chemistry/
Office Location: S-224 Lab: S-325

Rabie J. Gainous Science Annex

Office Phone: 386-481-2688,  Lab:386-481-2697 
Email Address:

Links : ResearchGate and  Rate my professor: 


  • Ph.D. [Biochemistry] J. N. Medical College, Aligarh M University Aligarh India
  • M.Phil [Medical Biochemistry], MS [Biochem] and BS [Chem major, Bio minor (Hons)] [Aligarh M University Aligarh India]

Brief Biographical Sketch

Dr. Vishwa D. Trivedi is an Associate Professor of Biochemistry at Bethune Cookman University [B-CU], Daytona Beach, FL, USA. He obtained his doctoral training in Protein Chemistry from Center for Cellular and Molecular Biology. As the Biochemistry program faculty at BCU, Vishwa Trivedi is involved with teaching chemistry/biochemistry courses along with active research focusing on microbial rhodopsin mediated protein-protein cross talk. Prior to joining BCU, Dr. Trivedi served as instructor at Center for Membrane Biology [in Department of Biochemistry and Molecular Biology] of University of Texas-Houston Medical School. He has served as research fellow at several premier research institutions and worked on protein structure-function projects involving NMR and x-ray crystallography of fusion domains of influenza, HIV-1 gp41 etc. 

Dr. Trivedi has served as Editorial board member [International J of Physiology and Biochemistry, Protein and protein letters etc], reviewer and panelist to various high impact scientific journals [e.g. J. Biological Chemistry, J. Biomol Dynamics, Process Biochemistry etc] and federal programs [NSF GRFP, DoD Program etc] respectively. Recently he has completed multi-year NIH-supported project serving as Principal Investigator and guided numerous researchers in his group.

Research Interests

My current research interest is related to “Protein Stability, Ligand binding and Protein-Protein Cross-Talk” in order to outline the signaling state of Anabaena Sensory Receptor Transducer, ASRT, a cognate signaling molecule found in freshwater Anabaena PCC 7120 involved in unique signaling cascade via light stimulation. 

My research group is involved with broad expertise ranging from molecular biology to protein biochemistry, with key emphasis on receptor activation and molecular basis of downstream signal relay using model integral photoreceptors, microbial rhodopsins. My research group proficiently utilizes wide spectrum of techniques ranging from gene cloning, site directed mutagenesis, overexpression, tagged and untagged protein purification, characterization, analysis, fluorescence based protein localization, phosphorylation assays, in vitro enzymatic assay, immunological approaches and basic cell biology tools. I have extensive experience in studying protein-protein, protein-lipid, protein-DNA and protein-ligand interaction using biochemical, analytical and classical biophysical applications. I have regularly provided support to fellow research staff with trouble shooting associated with applications to RNA, DNA and protein analysis, manipulation, characterization and radioactivity handling. I have guided research staff with various biochemical and molecular biology approaches in addition to spectroscopic applications and other advanced biophysical tools. I have provided course on analytical biochemical separation, bioinformatics of gene/protein analysis and structure function relationship of retinyledene binding receptors.

Currently we are working to explore the structure of unresolved motifs of microbial rhodopsin [in PCC 7120] and its cognate transducer using NMR. 


Invited speaker [past 5 years]

  • Invited 3rd CURESUB [Course Based Undergraduate Research Experiences for Students Underrepresented in Biology) Lecture on OMICS “NSF-RCN UBE supported project [Steering committee member] “Protein Structure-Function Exploration-an aligned initiative with bioinformatics analysis: A balanced route in Proteomics” Edward Waters Univ.  Mar. 18, 2022  
  • Invited national “Chalk-Talk” ASBMB 2022-Catalyst Conversation: Use of structured course design and classroom engaging activities support inclusive environment in senior biochemistry course” Feb. 12, 2022 [Session B (1-2 pm) speaker]
  • “PSFE [Protein Structure-Function Exploration] Initiative in Undergraduate Biochemistry and Independent Research Courses at Bethune Cookman University”-Invited spotlight talk (2021 ASBMB Big Data Conference June 20-25), session 3 (Dr. Cheryl P Bailey Chair) June 23, 2021. 
  • “Microbial Rhodopsin mediated Signal Transduction” STEM-Seminar series speaker at Daytona State College, (Host Dr. Jeffrey Squires), Daytona Beach, FL, Apr. 02, 2018. 
  •  “Stability, Ligand Binding and Phosphorylation of Anabaena Sensory Rhodopsin Transducer towards Putative Signaling State in Sensory Rhodopsin Mediated Protein-Protein Cross Talk” UCF Biophysics Seminar, Department of Physics, University of Central Florida, Orlando (Host Prof. Suren Tatulian), Orlando, FL, Dec.20,  2017.


Publications: [recent from BCU and with undergraduate reseachers]

Trivedi, V. D. (2022) “PSFE [Protein Structure-Function Exploration] Initiative in Undergraduate Biochemistry and Independent Research Courses” Biochem. & Mol. Biol. Edu., 50 [5], 473-475. 

Trivedi, V. D., Gundampati, R. G., and Kumar, T. K.S. (2021) “Purification and characterization of Anabaena Sensory Rhodopsin Transducer [ASRT] expressed with Glutathione S-Transferase fusion chimera” Protein Exp. and Purif. [Pending re-submission]

Trivedi, V. D., and Gautam, A. (2019) “Receptor Binding and Phosphorylation of Anabaena Sensory Rhodopsin Transducer towards Signaling via Protein-Protein Cross Talk”, FASEB J. , 33, [1-supplement issue] 631.44

Trivedi, V. D., Jones, T.S., and Gautam, A. (2018) “Ligand Binding and Modulation of Receptor Binding via Helical Face of Anabaena Sensory Rhodopsin Transducer, ASRT”, Protein Science, 27, [S1 proceedings, Nov].106

Gautam, A., and Trivedi, V. D. (2018) On the Role of Ser/Thr Kinase in phosphorylation of Anabaena Sensory Rhodopsin Transducer of Anabaena PCC 7120”, Protein Science, 27, [S1 proceedings, Nov] 105

Gautam, A., Jones, T. S., and Trivedi, V. D. (2018) “Ligand binding and phosphorylation of Anabaena Sensory Rhodopsin Transducer towards putative signaling state on sensory rhodopsin mediated protein-protein cross talk”  Anabaena PCC 7120”, FASEB J. , 32, [1-supplement issue]

Trivedi, V. D. , Jones, T.S., Walker, R. P., Gundampati, R. G., and Kumar, T. K.S. (2017) “Phosphorylation of Anabaena Sensory Rhodopsin Transducer: a Putative Signaling State in Sensory Rhodopsin Mediated Protein-Protein Cross Talk”, Protein Science, 26, [S1 proceedings]155-156.

Trivedi, V. D., Bedford, Q. X., Denmark, I. S., Pryce, X., Ellison, S. J., and Gautam, A. (2017) “Synthesis and optical characterization of cadmium sulfide quantum dots” Int. J. New Technologies in Sci. and Engg. 4(9), 21-25.

Trivedi, V. D., Jones, T.S., Walker, R. P. (2017) “Unusual Stability of Anabaena Sensory Rhodopsin Transducer from Anabaena PCC 7120”, The Int. J. Engg and Sci., 6, 35-40.

Trivedi, V. D., Jones, T., Walker, R., Henderson, R., and Kumar, T. K.S. (2016) “On the role of C-terminal domain of anabaena sensory rhodopsin transducer in unusual stability, ligand and receptor interaction”, Protein Science, 25 [S1 proceedings], 142.

Other Significant Publication [from Total 32]

Vogeley, L., Trivedi, V. D. , Sineshchekov, O. A., Spudich, E. N., Spudich, J.L., and Luecke, H. (2007)“Crystal structure of the Anabaena sensory rhodopsin transducer”J. Mol. Biol. 367, 741-751.

Bergo, V. B., Ntefidou, M., Trivedi, V. D., Amsden, J. J., Kralj, J. M., Rothschild, K. J., and Spudich, J. L. (2006) “Conformational changes in the photocycle of Anabaena sensory rhodopsin: Absence of the Schiff base counterion protonation signal” J. Biol. Chem 281, 15208-15214.

Sineshchekov, O. A., Spudich, E. N., Trivedi, V. D., and Spudich, J. L. (2006) Role of cytoplasmic domain in Anabaena sensory rhodopsin photocycling: vectoriality of Schiff base deprotonation” Biophys. J.  91, 4519-4527.

Sineshchekov, O. A., Trivedi, V. D., Sasaki, J., and Spudich, J. L. (2005) “Photochromicity of anabaena sensory rhodopsin, an atypical microbial receptor  with a cis-retinal light-adapted form” J. Biol. Chem. 280, 14663-14668.

Vogeley, L., Sineshchekov, O. A., Trivedi, V. D. , Sasaki, J., Spudich, J.L., and Luecke, H. (2004) “Anabaena Sensory Rhodopsin: A Photochromic Color Sensor at 2.0 Ao” Science 306, 1390-1393.

Trivedi, V. D., and Spudich, J. L. (2003) “Photostimulation of a Sensory Rhodopsin II/HtrII/Tsr Fusion Chimera Activates CheA-autophosphorylation and CheY-phosphotransfer in vitro” Biochemistry 42, 13887-13892. 

Jung, K.-H*., Trivedi, V. D.*, and Spudich, J. L. (2003)* Equal contributions “Demonstration of a sensory rhodopsin in eubacteria” Mol. Micro. 47, 1513-1522.

Trivedi, V. D., Cheng, S. F., Wu, C.-W., Karthikeyan, R., Chen, C.-J., and Chang, D. K. (2003) “The LLSGIV stretch of the N-terminal region of HIV-1 gp41 is critical for binding to model peptide, T-20” Protein Engg. 16, 311-317

Wu, C. –W., Cheng, S. F., Huang, W. N., Trivedi, V. D., Veeramuthu, B., Assen, B. K., Wu, W. G., and Chang, D. K. (2003) “Effect of alterations of amino-terminal glycine of influenza hemagglutinin fusion peptide on its structure, organization and membrane insertions” Biochim. Biophys. Acta 1612, 41-51.

Jung, K.-H., Spudich, E. N., Trivedi, V. D., and Spudich, J. L. (2001) “An archaeal photosignal-transducing module mediates phototaxis in Escherchia coli” J. Bact. 183, 6365-6371.

Chang, D. K., Cheng, S. F., and Trivedi, V. D. (2001)“Conformation and interaction with the membrane models of amino-terminal peptide of influenza virus hemagglutinin HA2 at fusion pH”  Arch. Biochem. Biophys. 396, 89-98.

Chang, D. K., Trivedi, V. D., Cheng, S. F., and Francis, S. (2001) “The leucine zipper motif of the envelope glycoprotein ectodomain of human immunodeficiency virus type 1 contains conformationally flexible regions as revealed by NMR and circular dichroism studies in different media”  J. Peptide Res. 57, 234-239

Trivedi, V. D., Yu, C., Veeramuthu, B., Francis, S., and Chang, D. K. (2000) “Fusion induced aggregation of model vesicles studied by dynamic and static light scattering”.Chem. Phys. Lipids 107, 99-106. 

Chang, D. K., Cheng, S. F., Trivedi, V. D., and Yang, S. H. (2000) “The amino-terminal region of fusion peptide of influenza virus hemagglutinin HA2 inserts into sodium dodecyl sulfate micelle with residues 16-18 at the aqueous boundary at acidic pH. Oligomerization and conformation flexibility”. J. Biol. Chem. 275, 19150-19158.

Samuel, D., Kumar, T. K., Ganesh, G., Jayaraman, G., Yang, P-W., Chang, M-M., Trivedi, V. D., Wang, S-L., Hwang-K-C., Chang, D. K., and Yu, C. (2000) “Proline inhibits aggregation during protein refolding”. Protein Sci. 9, 344-352.

Chang, D. K, Cheng, S. F., Trivedi, V. D., and Lin, K. L. (1999) “Proline affects oligomerization of coiled-coil by inducing a kink in a long helix”. J. Struct. Biol. 128, 270-279.

Trivedi, V. D., Cheng, S. F., Chien, W. J., Yang, S. H., Francis, S., and Chang, D. K. (1999) "Structure and conformational flexibility of the N-terminal region of gp41 of HIV-1 and its implications on viral fusion mechanism: A biophysical study". J. Bioscience 24 (S1 proceeding), 48. 

Chang, D. K, Cheng, S. F and Trivedi, V. D. (1999) "Biophysical characterization of the structure of the amino-terminal region of gp41 of  HIV-1: Implications on viral fusion mechanism". J. Biol. Chem. 274, 5299-5309.

Trivedi, V. D., Raman, B., Ramakrishna, T., and Rao, C.M. (1999) "Detection and assay for proteases using eye lens beta-crystallin as substrate". J. Biochem. Biophys. Methods 40, 49-55.

Trivedi, V. D., Vorum., H.,Honore, B., and Qasim, M. A. (1999) "Molecular basis of Indomethacin-human serum albumin interaction". J. Pharm. Pharmacol. 51, 591-600.

Rao, C. M., Raman, B., Ramakrishna, T., Rajaraman, K., Ghosh, D., Dutta, S., Trivedi, V. D. and Sukhaswami, M. B. (1998) "Structural perturbation of alpha-crystallin and its chaperone like activity".  Int. J. Biol. Macromol. 22, 271-281

Trivedi, V. D., Raman, B., Ramakrishna, T., and Rao, C. M. (1997) "Co-refolding denatured-reduced hen egg white lysozyme with acidic and basic protein". FEBS Lett. 418, 363-366.

Trivedi, V. D., Saxena, I., Siddiqui, M. U., and Qasim, M. A. (1997) "Interaction of  bromocresol green with different serum albumins studied by fluorescence quenching".  Biochem. Mol. Biol. Int. 43, 1-8.

Trivedi, V. D. (1997) "On the role of buried lysine residues in bromophenol blue-albumin interaction". Ital. J. Biochem. 46, 67-73.


Completed Grants

National Institute of General Medical Sciences, NIGMS, National Institute of Health, NIH: Support of Competitive Research, SCORE, SC-3 Program Project entitled “Ligand Binding and Signaling State of Anabaena Sensory Receptor Transducer”:  Principal Investigator, PI.

Award number: 1SC3GM113803-01 May 01, 2015-Jan. 31, 2020